This unique conference brought together key opinion leaders working on diverse mechanisms governing cellular fitness with a link to prominent human diseases. Biochemists, chemists and cellular biologists gathered to present an overview of their work and groundbreaking discoveries, as well as their most recent projects. Cells and organisms have evolved to survive challenging conditions and thereby acquired resilience to damages. Thus, cells devote a large fraction of their resources to prevent accumulation of damages through multiple mechanisms collectively known as quality control systems.
Central players of protein quality control are the protein degradation systems, ubiquitin and SUMO. The relaxed atmosphere of the seminar fostered lively discussions, particularly around the concept of serendipity, interdisciplinarity, and the importance of fundamental research.
Several presentations have indeed illustrated how the understanding of molecular mechanisms key to the wellbeing of the cells allowed the translation of that knowledge into therapeutic strategies, notably for possible treatments for cancers and neurodegenerative diseases. Crystal structures of the different subunits in complex have revealed mechanistic insights for the assembly, catalytic activity and specificity of these complexes. NEDD8 covalently and reversibly binds to the Cullin module, playing a key role in the transfer of ubiquitin moieties to target proteins.
As these targets have functions in the cell cycle, DNA repair, immunity… E3 ligases can be mutated in diseases or hijacked during virus infections.
Understanding of the Cullin-RING mechanism of action at the molecular level would thus allow the design of small molecules for targeted therapies. Yeast strains with a deletion for the SUMO-specific protease Ulp2 can adapt to this loss through disomy of two chromosomes, resulting in altered regulation of ribosome biogenesis. Long-term adaptation restored euploidy and was accompanied by loss-of-function mutations in other enzymes of the SUMO pathway, to reduce accumulation of SUMO substrates and restore homeostasis. Climate change and faith in the Pacific Islands. Is Policy Necessary?
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Université des Sciences et de la Technologie Houari Boumediene (USTHB) | pulachcati.gq
Search type Search Show advanced options. Core communities may be better informed about the science of global change and better equipped to respond to its impacts; peripheral communities often have less such awareness. These disparities are clearest in archipelagic island countries but have not been recognized by agencies seeking to enable adaptation. Adaptation to global change in the rural Pacific may succeed only when it combines scientific with traditional knowledge.
Science is needed to help communities cope with unprecedented environmental change while traditional knowledge localizes adaptation and expresses cultural resilience that will help sustain adaptation. The project will study 12 core and peripheral communities in the Federated States of Micronesia and Fiji. This will allow assessment of the influence of peripherality a measure of geographical distance from cores that is key to effective policy development and adaptive interventions.
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Patrick D. Conference Posters Lykins, A. Page created: 12 July Last modified: 7 November Tags autonomous coping capacity climate change Peripherality traditional knowledge. In rural parts of many Pacific Island countries, significant differences exist between cores and peripheries. So let us assess to what extent the goal was met, and what the participants have to say about their experience…. The main themes that emerged from the data analysis of the open-ended questionnaires, and from the semi-structured interviews that were conducted at the end of the project can be divided in two broad categories: All participants without exception pointed out the fact that the programme helped them to stop dramatising, and to tone down the importance of their problems.
They also realised that other PhD candidates felt exactly the same, that they were not the only ones to feel anxious or to lose self-confidence. The various exercises and techniques taught in the programme were appropriated differently, depending on individual needs. Interestingly, several participants noted that things seemed to have changed naturally, not always because they had decided to adopt new behaviours or ways of thinking, but because their perception had changed. This was clearly expressed by one participant:. I joined this programme to be able to identify whether problems that might emerge during my PhD are normal or not, and also to find out which tools I could use in such a case in order to analyse and solve the problems.
At the moment, I have no difficulty, it was merely preventive. From this perspective, the goal has been achieved, all the more since checklists are provided. There are some cases for which it seems difficult to help doctoral student solve their problems. The strongest obstacles seem to arise in contexts where the individual has little or no control over the situation, and very few options are available for them to get out of it.
Optimal byzantine resilient convergence in oblivious robot networks
For instance, a participant whose PhD research was not funded which is rather common in France, especially in disciplines such as social sciences or humanities attended all the four sessions. Although he was very happy with the programme, he declared at the end of the training that he did not manage to integrate any of the tools in his daily life and that everything went back to normal as soon as the programme was over.
His perception was confirmed by the scores in the questionnaires: Duration of the program. Most participants found the programme too brief.
They suggested to add at least one more session specifically devoted to the relationships with their supervisor s and to have three-hour session instead of two, in order to have more time for discussions. Here are a few comments from the participants:.
Related Résilience (Sciences Humaines) (French Edition)
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